Microorganisms in Recent Drug Discovery

Microorganisms  stay unrivalled in their ability to produce bioactive small molecules for drug development. Though, the core technologies used to discover microbial natural products have not evolved considerably over the past several decades, resulting in a shortage of new drug leads. Advances in DNA-sequencing and bioinformatics technologies currently build it possible to rapidly determine the clusters of genes that encode bioactive compounds and to make computer predictions of chemical structure based on gene sequence information. These structure predictions can be used to determine new chemical entities and supply necessary physicochemical “handles” that lead compound purification and structure confirmation. Industrialization of this process provides a model for rising the efficiency of natural-product discovery. The application of advanced genomics and bioinformatics technologies is  currently  poised to revolutionize natural-product discovery and lead a renaissance of interest in microorganisms as a supply of bioactive compounds for drug development.

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