Antimicrobial Agents and Novel Vaccines

By reducing the need for antimicrobial use, vaccines can reduce the prevalence of resistance and also reduce its impact by reducing the total number of cases. Vaccines may allow the use of narrower-spectrum antibiotics for experimental therapy by reducing the number of pathogens that may be responsible for a specific clinical syndrome. Such results can be exacerbated by herd immunity, which extends safety in the population for unvaccinated people. Because a great deal of resistance selection is due to the selection of bystander members of the normal flora, vaccination may reduce resistance pressure even in non-vaccinated pathogens. Many vaccines have disproportionate effects within the target species on drug-resistant lineages, an advantage that could be used more intentionally in vaccine layout.

 

  • Hib conjugate vaccine
  • Respiratory vaccine

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